| ornithine aminotransferase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| EC number | 2.6.1.13 | ||||||
| CAS number | 9030-42-6 | ||||||
| Databases | |||||||
| IntEnz | IntEnz view | ||||||
| BRENDA | BRENDA entry | ||||||
| ExPASy | NiceZyme view | ||||||
| KEGG | KEGG entry | ||||||
| MetaCyc | metabolic pathway | ||||||
| PRIAM | profile | ||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||
| Gene Ontology | AmiGO / EGO | ||||||
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| ornithine aminotransferase (gyrate atrophy) | |
|---|---|
| Identifiers | |
| Symbol | OAT |
| Entrez | 4942 |
| HUGO | 8091 |
| OMIM | 258870 |
| RefSeq | NM_000274 |
| UniProt | P04181 |
| Other data | |
| EC number | 2.6.1.13 |
| Locus | Chr. 10 q26 |
Ornithine aminotransferase is an enzyme involved in the ultimate formation of proline from ornithine. Ornithine aminotransferase forms the initial intermediate in this process. It catalyzes the reverse reaction as well, and is therefore essential in creating ornithine from the starting substrate proline. Glutamate acts as the amine donor for ornithine aminotransferase, forming α-ketoglutarate. In the reverse direction, α-ketoglutarate accepts the amine group, forming glutamate and leading to the ultimate conversion of proline to ornithine.
Ornithine aminotransferase catalyzes the following reaction:
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